And animal studies suggest that high concentrations of hydrogen peroxide can cause irreversible cell damage and may enhance carcinogens.
2.
If exposure is too high or for prolonged durations irreversible cell damage can occur which eventually leads to cell death.
3.
Changes in the pH of arterial blood ( and therefore the extracellular fluid ) outside this range result in irreversible cell damage.
4.
The consequence of the drugs actions are irreversible cell swelling and lysis ( e . g . ouabain at very high doses ).
5.
Structural signs that indicate irreversible cell injury and the progression of necrosis include dense clumping and progressive disruption of genetic material, and disruption to membranes of cells and organelles.
6.
P16 / Rb pathway collaborates with the mitogenic signaling cascade for the induction of reactive oxygen species, which activates the protein kinase C delta, leading to an irreversible cell cycle arrest.
7.
The therapeutic effect is created by raising the tissue temperature during energy delivery ( sonication ) which causes thermal ablation and defined regions of protein denaturation, irreversible cell damage and coagulative necrosis at the target.
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